Table 2. Association of rs4936356 with quantitative metabolic traits in Greenlanders.
| Trait | N | β (SD) | SE | β (trait unit) | p-value | p-value_BMIadj |
|---|---|---|---|---|---|---|
| Body composition | ||||||
| BMI (kg/m2) | 4626 | -0.14 | 0.03 | -0.64 | 3.2x10-8 | NA |
| Height (cm) | 4648 | -0.01 | 0.02 | -0.03 | 0.793 | 0.979 |
| Weight (kg) | 4631 | -0.13 | 0.03 | -1.68 | 6.7x10-7 | 0.233 |
| Waist (cm) | 4594 | -0.12 | 0.03 | -1.52 | 1.4x10-6 | 0.128 |
| Hip (cm) | 4592 | -0.11 | 0.03 | -0.85 | 2.7x10-5 | 0.601 |
| Lean mass (kg) | 2702 | -0.14 | 0.03 | -0.84 | 1.9x10-6 | 0.143 |
| Fat mass (kg) | 2702 | -0.18 | 0.03 | -1.66 | 3.2x10-8 | 0.019 |
| Fat (%) | 2713 | -0.17 | 0.03 | -1.39 | 1.1x10-7 | 0.105 |
| VAT (cm) | 2693 | -0.14 | 0.03 | -0.30 | 1.6x10-5 | 0.169 |
| SAT (cm) | 2683 | -0.12 | 0.03 | -0.16 | 0.0002 | 0.816 |
| Glucose homeostasis | ||||||
| Fp glucose (mmol/l) | 3693 | -0.05 | 0.03 | -0.04 | 0.059 | 0.798 |
| 2h-p glucose (mmol/l) | 3437 | -0.01 | 0.03 | -0.01 | 0.770 | 0.419 |
| HbA1c (%) | 4624 | -0.01 | 0.02 | -2.6x10-4 | 0.568 | 0.411 |
| Insulin sensitivity | ||||||
| Fs insulin (pmol/l) | 3691 | -0.11 | 0.03 | -2.16 | 0.0002 | 0.368 |
| 2h-s insulin (pmol/l) | 3437 | -0.03 | 0.03 | -0.53 | 0.310 | 0.743 |
| HOMA-IR (mmol/lxpmol/l) | 3684 | -0.10 | 0.03 | -0.12 | 0.0002 | 0.380 |
| Lipids | ||||||
| Fs triglyceride (mmol/l) | 4124 | -0.06 | 0.03 | -0.05 | 0.025 | 0.504 |
| Fs HDL-cholesterol (mmol/l) | 4652 | 0.08 | 0.03 | 0.04 | 0.0015 | 0.229 |
| Fs cholesterol (mmol/l) | 4517 | 0.03 | 0.03 | 0.03 | 0.279 | 0.06 |
Results are shown for an additive genetic model. β (SD) is the effect size estimated using quantile transformed values of the trait, and β (trait unit) is the effect size estimated using untransformed values. The p-values were obtained from the quantile transformed value based analyses, with (p-value) or without BMI (p-value_BMIadj) included as a covariate. F, fasting; HOMA-IR, homeostasis model assessment of insulin resistance; NA, not applicable; p, plasma; SAT, subcutaneous adipose tissue; s, serum; SD, standard deviation; SE, standard error; VAT, visceral adipose tissue.