Table 3.

Descriptive statistics for laboratory parameters per biopsy and Mann Whitney results between serial renal biopsies.

No significant difference was recorded in renal parameters of disease activity between biopsies. Serum C3 levels increased significantly between the first and the second biopsy (p=0.012). Antids DNA titer decreased between the fourth and the fifth biopsy (p=0.019).

Variable	Biopsy-1	Biopsy-2	Biopsy-3	Biopsy-4	Biopsy-5
	N = 35	N=35	N=13	N=5	N=4
Cr (mg/dL)	1.21±0.81	1.05±0.77	1.27±1.08	1.86±1.30	1.03±0.32
Z-test*		−1.635	−0.466	−0.529	−1.169
p		0.102	0.641	0.597	0.243
e GFR (mL/min/1.73m2 )	77±30.52	89.44±32.74	76.19±30.84	65.20±56.91	74.50±19.23
Z-test*		−1.78	−0.517	−0.522	−1.155
p		0.075	0.605	0.602	0.248
Proteinuria (g/24h)	3.02±2.65	3.73±3.23	4.55±2.88	5.30±2.59	2.23±1.85
Z-test*		−0.876	−0.136	−0.419	−0.289
p		0.381	0.892	0.675	0.773
C3 (mg/dL)	51.02±29.49	73.76±40.99	69.46±28.23	73.70±32.91	73.43±30.23
Z-test*		−2.52	−0.396	−0.245	0.000
p		0.012**	0.692	0.806	1.000
C4 (mg/dL)	8.95±6.36	13.32±9.67	11.28±7.63	6.44±2.98	10.03±6.82
Z-test*		−1.94	−0.89	−1.225	−1.443
p		0.052	0.373	0.221	0.149
ds DNA (IU/mL)	47.01±41.55	41.01±39.56	52.84±42.37	54.60±42.81	28.73±25.29
Z-test*		−0.47	−1.005	−0.768	−2.337
p		0.638	0.315	0.443	0.019**

Data are expressed as mean±SD.

^*Mann Whitney test vs previous biopsy, Confidence interval:

^**95%,

^***99% Normal values of C3:75–140mg/dL, C4:10–40mg/dL, dsDNA: 0–7IU/mL