Table 1.
Correlation between senescence-associated secretory factors in synovial fluid and serum and osteoarthritis.
| Analyte | Category | SF pg/mL Median (IQR) |
Serum pg/mL Median (IQR) |
Rho | p |
|---|---|---|---|---|---|
| STRONGLY CORRELATED (Rho≥0.5) | |||||
|
| |||||
| CXCL13 | Chemokine | 103.6 (15.2) | 92.8 (62.5) | 0.7479 | 0.03 |
| uPAR | Proteinases | 2322.5 (1894) | 1067.9 (798.7) | 0.6474 | 0.08 |
| MMP12 | Proteinases | 147.3 (24.9) | 159.7 (17.1) | 0.6350 | 0.09 |
| ICAM-1 | Adhesion molecule | 161834.5 (165368) | 157307.5 (230114) | 0.6290 | 0.09 |
| CCL11 | Chemokine | 177.9 (62.9) | 236.3 (44.8) | 0.6116 | 0.11 |
| IL-1b | Interleukin | 20.2 (1.04) | 24.6 (2.86) | 0.5795 | 0.13 |
| CXCL1 | Chemokine | 507.6 (199.54) | 446.4 (253.49) | 0.5671 | 0.14 |
| IGFBP7 | Growth factor | 17024.5 (5899) | 28820.5 (15871) | 0.5609 | 0.15 |
| PAI-1 | Protease inhibitor | 14487.0 (5467) | 14487.0 (0) | 0.5574 | 0.15 |
| CCL1 | Chemokine | 8.5 (2.28) | 8.7 (1.12) | 0.5335 | 0.17 |
| IGFBP3 | Growth factor | 263111 (276567) | 827635 (773075) | 0.5272 | 0.18 |
| MMIF | Chemokine | 11578.5 (4044) | 1637.5 (599.00) | 0.5113 | 0.20 |
IQR: interquartile range; uPAR: urokinase receptor; ICAM: intercellular adhesion mollecule-1; IGFBP: Insulin growth factor binding protein; MMIF: Macrophage migration inhibitory factor; PAI: plasminogen activator inhibitor.