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The schematics shows the Scd2 scaffold-mediated positive feedback on Cdc42 activation (wide, pale red arrow) and input by Ras1-GTP. By promoting Scd1 activity, Ras1-GTP amplifies the positive feedback. Positional cues on Cdc42 are transmitted through both Ras1-GTP and Pak1. GAP, GTPase activating protein; GEF, guanine nucleotide exchange factor.
