Table 4.
Association of HIV-specific variables with acute coronary syndrome type and revascularization for persons living with HIV who presented with acute coronary syndrome between 2004 and 2013.
| Variable, n (%) | STEMI, n = 25 | NSTEMI/UA, n = 61 | P value | Crude OR (95% CI) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) |
|---|---|---|---|---|---|---|
| CD4+ cell count (cells/μl) | 0.87 | |||||
| <200 | 8 (33) | 15 (28) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |
| 200–499 | 9 (37) | 23 (43) | 0.73 (0.23–2.33) | 0.46 (0.12–1.74) | 0.20 (0.04–1.01) | |
| ≥500 | 7 (29) | 15 (29) | 0.88 (0.25–3.03) | 0.76 (0.17–3.39) | 0.36 (0.07–1.89) | |
| Any ART | 19 (76) | 46 (75) | 0.95 | 1.03 (0.35–3.06) | 0.89 (0.24–3.32) | 0.72 (0.17–3.16) |
| PIc | 15 (79) | 31 (69) | 0.41 | 1.69 (0.48–6.03) | 1.72 (0.42–7.05) | 2.87 (0.64–12.98) |
| ABCc | 7 (37) | 11 (24) | 0.31 | 1.80 (0.57–5.72) | 2.40 (0.63–9.13) | 5.08 (1.02–25.26) |
| HIV viral load (copies/ml) | 0.43 | |||||
| Undetectable | 13 (57) | 25 (58) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |
| 50–1000 | 2 (9) | 8 (19) | 0.48 (0.09–4.84) | 0.45 (0.07–2.75) | 0.46 (0.08–2.78) | |
| >1000 | 8 (35) | 10 (23) | 1.54 (0.49–4.84) | 1.48 (0.38–5.76) | 3.68 (0.68–19.90) | |
| CABG or PCI, n = 63 | No CABG or PCI, n =23 | P value | Crude OR (95% CI) | Adjusted ORa (95% CI) | Adjusted ORb (95% CI) | |
| CD4+ cell count (cells/μl) | 0.10 | |||||
| <200 | 14 (25) | 9 (40) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |
| 200–499 | 27 (49) | 5 (23) | 3.47 (0.98–12.35) | 5.25 (1.31–21.02) | 1.68 (0.22–12.80) | |
| ≥500 | 14 (18) | 8 (36) | 1.13 (0.34–3.76) | 1.43 (0.38–5.42) | 0.25 (0.03–1.79) | |
| Any ART | 50 (79) | 15 (65) | 0.18 | 2.05 (0.72–5.88) | 3.32 (0.99–11.17) | 1.18 (0.22–6.22) |
| PIc | 36 (57) | 10 (45) | 0.34 | 1.03 (0.28–3.83) | 1.21 (0.31–4.79) | 2.29 (0.48–11.03) |
| ABCc | 12 (19) | 6 (27) | 0.41 | 0.42 (0.12–1.46) | 0.59 (0.16–2.21) | 1.42 (0.24–8.48) |
| HIV viral load (copies/ml) | 0.58 | |||||
| Undetectable | 30 (61) | 8 (47) | 1.00 (ref) | 1.00 (ref) | 1.00 (ref) | |
| 50–1000 | 7 (14) | 3 (18) | 0.62 (0.13–2.97) | 0.54 (0.11–2.75) | 0.48 (0.08–3.07) | |
| >1000 | 12 (24) | 6 (35) | 0.53 (0.15–1.87) | 0.46 (0.11–1.93) | 4.35 (0.28–67.36) |
ABC, abacavir; ACS, acute coronary syndrome; ART, antiretroviral therapy; CABG, coronary artery bypass graft; CI, confidence interval; NSTEMI, non-STEMI; OR, odds ratio; PI, protease inhibitor; PLWH, persons living with HIV; STEMI, ST-segment elevation myocardial infarction; UA, unstable angina.
a
Adjusted for age, sex, race, smoking status, and year.
b
Adjusted for age, sex, race, smoking status, year, and Gensini score.
c
Among those receiving ART.