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Insulitis occurs exclusively in the islet regions containing the largest HA deposits. Violin plots of HA+ areas in islets without (LCA−) or with (LCA+) immune cells for the (a) aAb−, (b) aAb+HAlow, (c) aAb+HAhigh and (d) aAb+HAhighLCAhigh tissues. Islet HA+ areas are shown on a log10 scale. The total number of LCA− or LCA+ islets in each group is indicated. LCA+ cells/100 islets: 3 ± 1 in (a) and (b); 5 ± 2 in (c); 47 ± 36 in (d)
