Figure - PMC

Skip to main content

View full-text article in PMC

. Author manuscript; available in PMC: 2021 Mar 1.

Published in final edited form as: Diabetologia. 2020 Jan 6;63(3):549–560. doi: 10.1007/s00125-019-05066-7

Fig. 6 — (a) Islet HA⁺ areas, insulitis and beta cell mass in individual aAb⁺ donors. Islet HA⁺ areas are shown as mean values obtained from the islets examined in each pancreas. Between 250 and 560 islets were analysed per pancreas. For ‘islet HA⁺ area’ and ‘beta cell mass’, the size of each red circle is proportional to the mean value, which is indicated within the circle. The pie charts represent the percentage of islets with HA⁺ areas falling within each of the HA⁺ area size categories or the percentage of islets with LCA⁺ cells. HLA genotype and aAb status are also shown for each donor. See ESM Fig. 6 for further analyses. (b) Whole slide images of pancreas tissue sections from donor 1 (aAb⁺HA^high) and donor 13 (aAb⁺HA^low). The blue, green, and red circles show the islet border and the indicate islets with HA-stained areas ≤500 μm², 501–2000 μm² and >2000 μm², respectively. Scale bars, 2000 μm. N/D, not determined

Fig. 6 — (a) Islet HA⁺ areas, insulitis and beta cell mass in individual aAb⁺ donors. Islet HA⁺ areas are shown as mean values obtained from the islets examined in each pancreas. Between 250 and 560 islets were analysed per pancreas. For ‘islet HA⁺ area’ and ‘beta cell mass’, the size of each red circle is proportional to the mean value, which is indicated within the circle. The pie charts represent the percentage of islets with HA⁺ areas falling within each of the HA⁺ area size categories or the percentage of islets with LCA⁺ cells. HLA genotype and aAb status are also shown for each donor. See ESM Fig. 6 for further analyses. (b) Whole slide images of pancreas tissue sections from donor 1 (aAb⁺HA^high) and donor 13 (aAb⁺HA^low). The blue, green, and red circles show the islet border and the indicate islets with HA-stained areas ≤500 μm², 501–2000 μm² and >2000 μm², respectively. Scale bars, 2000 μm. N/D, not determined