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Senescent cells develop the senescent-associated secretory phenotype (SASP). Senescent cells secrete significant amounts of IL-6 and IL-8, cytokines which can act in both an autocrine or paracrine manner to promote cellular senescence. IL-6 through IL-6 receptor (IL-6R) and/or IL-8 (through CXCR2) act in concert with cellular stress induced by reactive oxidative species (ROS) to induce the senescent phenotype
