Table 1.

Recent studies linking age and clinical outcome in NAFLD and HCV in addition to key articles discussing the cellular mechanisms of liver aging

Topic	Authors	Year	Summary	Ref
NAFLD and NASH	Angulo et al.	1999	Older age is a risk factor for fibrosis in patients with NASH	[101]
	Ratziu et al.	2000	Age >50 is a risk factor for NAFLD	[102]
	Hossain et al.	2009	Old age is a risk factor for fibrosis in NAFLD	[103]
	Fierbinteanu-Braticevici et al.	2011	Older age is a risk factor for NASH	[104]
	Stepanova et al.	2013	Older age is a risk factor for increased mortality in NAFLD	[105]
	Bhala et al.	2013	Older age is a risk factor for fibrosis in patients with NAFLD	[106]
HCV	Pradat et al.	2007	Older age of HCV infection is associated with increased progression to fibrosis	[107]
	Kirk et al.	2013	Prevalence of fibrosis in HIV and HCV co-infected patients	[108]
	Butt et al.	2015	Age is associated with increased risk of cirrhosis and hepatic decompensation in HCV infection	[109]
	Rueger	2015	Age of infection contributes to the rate of fibrosis progression in HCV	[110]
Cellular mechanisms of liver aging	Videla et al.	2001	Mouse model of Kupffer cell aging	[111]
	Friedman et al.	2004	A review of the mechanisms of hepatic fibrosis	[112]
	Hilmer et al.	2007	The effect of age on Kupffer cell activity	[93]
	Mahrouf-Yorgov et al.	2010	Increased susceptibility to liver fibrosis and inflammation	[70]
	Collins et al.	2013	Murine model describing liver injury, fibrosis, and the role of liver macrophages	[71]
	Hong et al.	2014	C/EBP Proteins in the context of liver aging and regeneration	[72]