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. Author manuscript; available in PMC: 2020 Feb 5.
Published in final edited form as: Chem Res Toxicol. 2014 Apr 21;27(5):919–930. doi: 10.1021/tx500072m

Figure 5. Locations of genetic pol κ variations.

Figure 5.

Structure of human pol κ21−517 (PDB code, 2OH2) bound to primer/template DNA and incoming nucleotide is shown using Pymol. Pol κ21−517 is shown in cartoon ribbons, and the primer/template DNA and dNTP are shown in gray sticks. The N-clasp, finger, palm, thumb, and PAD domains are colored orange, yellow, red, green, and blue, respectively. The amino acid residues (in purple spheres) of genetic pol κ variants are indicated. The structural domains of pol κ are shown in the upper schematic diagram using DOG (version 2.0),54 where locations of amino acids related to eight studied variations are indicated.