TABLE 2.

Microbiology and phage-associated parameter values

Parameter of model	Value	Source from which estimated
Combination therapy model
rP, maximum growth rate of phage-sensitive (antibiotic- resistant) bacteria	0.75 h−1	P. aeruginosa murine pneumonia model (40)
KC, carrying capacity of bacteria	1 × 1010 CFU/g	Assuming ∼4 times above the typical bacterial density (2.4 × 109 CFU/g) in wild-type mice 24 h postinfection
β, burst size of phage	100	Estimated from reference 5
ω, decay rate of phage	0.07 h−1	Estimated from reference 5
ε, killing rate parameter of immune response	8.2 × 10−8 g/(h cell)	Set such that εKI gives the maximum granulocyte killing rate (40)
α, maximum growth rate of immune response	0.97 h−1	Fitting of neutrophil recruitment data (41)
KI, maximum capacity of immune response	2.4 × 107 cell/g	Fitting of neutrophil recruitment data (41)
KI, maximum capacity of immune response (immunodeficient mice)	Same as I0	No innate immune activation
KD, bacterial concentration at which immune response is half as effective	4.1 × 107 CFU/g	Corresponds to lethal dose of about 5.5 × 106 CFU/lungs
KN, bacterial concentration when immune response growth rate is half its maximum	107 CFU/g	In vitro data of TLR5 response to PAK strain (42)
B0, initial bacterial density (in presence or absence of the innate immune response)	7.4 × 107 CFU/g	Total inoculum of 107 CFU
P0, initial phage dose (in presence or absence of the innate immune response)	7.4 × 108 PFU/g	Total phage dose of 108 PFU
I0, initial immune response	2.7 × 106 cell/g	Fitting of neutrophil recruitment data (41)
I0, initial immune response (immunodeficient mice)	0 cell/g	Assuming no primary innate immunity
HM model
$\tilde{\varphi }$, nonlinear phage adsorption rate	5.4 × 10−8 (g/PFU)γ h−1	Estimated from reference 5
γ, power law exponent in phage infection rate	0.6	Estimated from reference 5
PS model
ϕ, linear phage adsorption rate	5.4 × 10−8 (g/PFU) h−1	Estimated from reference 5
PC, phage concentration at which phage infection rate is half saturated	1.5 × 107 PFU/g	Estimated from reference 5
LI model
ϕ, linear phage adsorption rate	5.4 × 10−8 (g/PFU) h−1	Estimated from reference 5