TABLE 3.

Additional parameter values associated with the effects of antibiotics

Antibiotic (ciprofloxacin) parameter	Value	How calculated
κkill, maximum antibiotic killing rate	18.5 h−1	Fitting an Emax model to antibiotic kill curves (18)
EC50, concentration of antibiotic at which the killing rate is half its maximum	0.3697 μg/ml	Calculated using the MIC of ciprofloxacin for the phage-resistant PAPS strain (7)
${\text{EC}}_{B_P}$, concentration of antibiotic at which the killing rate is half its maximum	4.070 μg/ml	Calculated using the MIC of ciprofloxacin for the phage-sensitive PAPS strain (7)
H, Hill coefficient	1	From reference 18
MIC of ciprofloxacin for P. aeruginosa PAPS phage-resistant strain	0.014 μg/ml	From reference 7
MIC of ciprofloxacin for P. aeruginosa PAPS phage-sensitive strain	0.172 μg/ml	From reference 7
θ, antibiotic elimination rate from serum samples	0.53 h−1	Estimated from antibiotic concentration-vs-time curves; concentration of ciprofloxacin was measured in serum samples of P. aeruginosa-infected mice (38)
Antibiotic-sensitive bacterial parameters
*μ1, probability of emergence of antibiotic-sensitive (phage-resistant) mutants per cellular division	2.85 × 10−8	Estimated from experimental measurements (39)
μ2, probability of emergence of phage-sensitive (antibiotic-resistant) mutants per cellular division	2.85 × 10−8	Approximated to the estimates from reference 39
rA, maximum growth rate of antibiotic-sensitive (phage-resistant) bacteria	0.675 h−1	10% tradeoff between resistance against phage and growth rate (43)