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. 2020 Feb 5;6(6):eaay9258. doi: 10.1126/sciadv.aay9258

Fig. 1. Hu1B7 and aglycosylated hu1B7-N297A antibodies confer similar protection against B. pertussis challenge in mice.

Fig. 1

Four-week-old Balb/c mice were administered antibody or PBS intraperitoneally in a 200-μl volume 2 hours before infection with 107 CFU B. pertussis (Bp) strain D420. Infection severity was assessed after 7 days by (A) CD45+ leukocytosis (WBC) and (B) B. pertussis lung colonization (no colonies were recovered for PBS-treated, uninfected mice). Significance was determined by two-way analysis of variance (ANOVA) with Tukey post hoc test; *P < 0.05; ****P < 0.0001.