Figure 3.

Calcineurin activation during reconsolidation alters synaptic plasticity through a postsynaptic reduction in AMPAR current. Following SA, rats received a brief cue reactivation (3 CS) session followed immediately by infusion with either CGA or Veh. Twenty-four hours later, ex vivo recordings were performed in the LA. A, Input/output curve demonstrating average evoked EPSC amplitude across various stimulation intensities. Intra-LA CaN activation by CGA decreases EPSC amplitude. B, No significant differences in PPR between groups. CaN activation by CGA significantly reduced (C) AMPA–NMDA and (D) AMPA current, but had no effect on (E) NMDA current. Data are expressed as mean ± SEM; n in bars, number of rats (number of neurons). *p < 0.05. Insets, Sample average EPSC traces. Scale bars: 50 ms, 200 pA.