Figure 4.

Activating calcineurin during cue extinction fails to significantly reduce subsequent cue-induced reinstatement. A, B, Mean number of active lever presses per day during SA and IE. There were no significant differences in active lever presses during (A) SA or (B) IE. Following IE, rats were placed back in training context and received a cue-extinction (60 CS) session followed immediately by infusion with either CGA or Veh. C, Mean number of active lever presses during the last day of instrumental extinction compared with cue-induced reinstatement. CGA activation following 60 CS does not significantly reduce active lever responding during reinstatement. D, Effect of CGA on extinction is mitigated by co-infusion of CaN inhibitor, FK-506. Insets, Histological verification of guide cannulae placements throughout the anterior–posterior extent of the LA. Data are expressed as mean ± SEM; n in bars, number of rats. *p < 0.05.