Figure 9.

The incidence of naturally occurring AD reduces after grafting embryonic NSCs in the injured spinal cord. A, Representative MAP tracer is shown over a 24 h period (n = 6 or 8 per group). Vertical line indicates an episode of AD, detected by using the algorithm. B, A typical spontaneous AD is shown in time-stretched tracers of MAP and HR in a RN-NSC-grafted rat, which is manifested by suddenly increased MAP and simultaneously decreased HR. Vertical dotted lines indicate the beginning and end of AD. Horizontal black line indicates the baseline of MAP. Horizontal gray line indicates a smoothed curve. C, Statistical analysis reveals significantly less events of AD in rats grafted with RN-NSCs than in those with injury alone (one-way ANOVA p < 0.05, Fisher's PLSD: both *p < 0.05). Statistically, animals receiving RN-NSCs have no different occurrence of AD compared with those receiving SC-NSC graft (p = 0.91). NS, not significant.