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. Author manuscript; available in PMC: 2021 Feb 15.
Published in final edited form as: J Immunol. 2020 Jan 3;204(4):1035–1046. doi: 10.4049/jimmunol.1901206

FIGURE 4. All B. theta CPSs stimulate the innate immune system in a MyD88-dependent manner, but anti-stimulatory CPSs activate the innate immune system more weakly than pro-stimulatory CPSs.

FIGURE 4.

(A) Percentage of iNOS expressing C57BL/6 or MyD88−/− BMDM after a 24 hour culture with CPS1, CPS8, or Acap (n = 4, three experiments).

(B and C) IL-6 and TNF levels in picogram per milliliter produced by (B) C57BL/6 or MyD88−/− BMDM and (C) C57BL/6 BMDC after a 24 hour culture with CPS1, CPS8, or Acap (n = 4–6, three experiments).

Data represent mean ± SEM. One-way ANOVA analysis (A and B) ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001, ∗∗∗∗p < 0.0001, (C) ∗p < 0.05, ∗∗∗∗p < 0.0001.