Figure 3. CBFA2T3-GLIS2 induces over-expression of CD56 (NCAM1) in healthy normal cord blood cells.
A) Surface immunophenotype of mock-transduced cord blood cells cultured for 6 weeks (green), B) CBFA2T3-GLIS2 transduced cord blood cells cultured for 10 weeks (purple), and C) patient with CBFA2T3-GLIS2 and RAM phenotype (red). Patient data for CD64 and CD36 not available. Morphology of CBFA2T3-GLIS2 transduced cells includes D) megakaryocytic features, such as cytoplasmic blebs, noted with arrow and E) cells express megakaryocytic surface markers CD41 and CD61.