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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Clin Cancer Res. 2019 Nov 12;26(3):726–737. doi: 10.1158/1078-0432.CCR-19-1800

Figure 4. A cohort of 24 CBFA2T3-GLIS2 AML patient samples were employed in transcriptional profiling for mRNA and miRNA differential expression analysis and gene-set enrichment analysis.

Figure 4.

A) Schematic representation of the data types and transcriptomic analyses in this study. B) Heatmap of positively and negatively (blue) enriched pathways from gene-set enrichment analysis of the CBFA2T3-GLIS2 cohort. Pathways (rows) have Benjamini-Hochberg adjusted p-values ≤ 0.001. The enrichment statistic for the gene-set enrichment analysis are denoted in each tile and were derived from a two-sample t-test for differential expression of gene sets. C) Differentially expressed genes involved in Hedgehog signaling or its cross-talk found to be up-regulated in CBFA2T3-GLIS2 tumors.