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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Clin Cancer Res. 2019 Nov 12;26(3):726–737. doi: 10.1158/1078-0432.CCR-19-1800

Figure 5. CBFA2T3-GLIS2 cases over-express a number of cell adhesion, cell-surface, and extracellular matrix associated genes.

Figure 5.

A) Top 15 Significantly upregulated cell adhesion, extracellular matrix, and cell-surface associated genes in CBFA2T3-GLIS2 AML. B) Unsupervised hierarchal clustering of 1,049 pediatric AML patients using the 90th percentile of highest upregulated cell-surface genes (FDR < 0.001). Color bars indicate primary cytogenetic code, M7 AML classification, fusion status (CBFA2T3-GLIS2 in red), and trisomies associated with CBFA2T3-GLIS2. The patients with similar cell-adhesion/extracellular matrix associated gene expression profiles are highlighted by the black box.