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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Clin Cancer Res. 2019 Nov 12;26(3):726–737. doi: 10.1158/1078-0432.CCR-19-1800

Figure 6. CBFA2T3-GLIS2 AML have a distinct miRNA expression profile compared to the fusion-negative population and up-regulated miRNAs may inhibit tumor suppressor and apoptotic genes.

Figure 6.

A) Volcano plot illustrating the over and under expressed miRNAs in CBFA23-GLIS2 compared to fusion-negative patients. B) The 5 most up and down regulated miRNAs ranked by absolute log2 fold-change. C) Predicted and validated miRNA-mRNA interactions with apoptosis and tumor suppressor genes found to be significantly down-regulated in CBFA2T3-GLIS2 cases.