Table I:
Peptide binding residues in MHC class I molecules from different lineages
| Sample | Position of Peptide Binding Residues* | ||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| α1 domain | α2 domain | ||||||||||||||||||||||||||||||||||||
| 5 | 7 | 9 | 22 | 24 | 34 | 45 | 59 | 63 | 66 | 67 | 70 | 73 | 74 | 77 | 80 | 81 | 84 | 95 | 97 | 99 | 114 | 116 | 118 | 123 | 124 | 143 | 146 | 147 | 152 | 155 | 156 | 159 | 160 | 163 | 167 | 171 | |
| nurse shark Gici UAA | L | Y | F | F | A | V | M | Y | E | T | L | W | W | G | N | I | L | R | Y | L | C | V | H | W | F | I | T | K | W | F | G | T | Y | L | I | W | Y |
| nurse shark Gici UAA-NC1 | L | . | Y | F | T | D | D | . | Q | I | A | W | V | G | N | T | A | . | I | L | V | Y | Y | W | . | I | . | . | . | F | Q | T | . | L | I | W | . |
| banded hounshark Trsc UAA | L | . | H | F | I | V | T | . | N | K | A | W | W | G | N | I | L | . | L | R | S | F | F | W | L | I | . | . | . | L | Q | W | . | L | I | W | . |
| spiny dogfish Sqac UAA | L | . | Y | F | A | V | M | . | E | K | Q | W | I | G | D | T | L | . | L | V | Y | F | Y | W | L | I | . | . | . | L | Q | R | . | L | E | W | . |
| horn shark Hefr UAA | Y | . | Y | F | A | N | M | S | W | R | L | W | I | G | N | T | A | . | V | T | Y | Y | D | W | Y | I | . | . | . | Y | G | W | . | L | T | W | . |
| clearnose skate Raeg UAA | L | . | Y | F | A | V | L | . | E | K | L | W | G | F | N | T | L | . | I | R | F | S | Y | W | L | I | . | . | . | I | Q | N | . | L | T | W | . |
| shovelnose guitarfish Rhpr UAA | L | . | Y | F | T | T | D | . | Q | I | L | H | T | F | N | I | A | . | F | R | Y | D | F | W | . | I | . | . | . | W | G | N | . | L | I | W | . |
| elephant shark Cami UAA | L | . | Y | F | I | V | M | . | Q | T | A | W | T | Y | N | T | V | . | V | Q | Y | I | Y | Y | . | I | . | . | . | L | Q | E | . | L | I | W | . |
| horn shark Hefr UBA | L | . | F | F | G | V | L | A | K | L | A | R | T | F | R | I | L | . | I | M | T | N | Y | W | . | L | I | N | . | G | G | W | . | L | E | W | . |
| whale shark Rhty UBA | L | . | L | F | I | I | L | A | K | L | A | Q | D | F | F | R | I | . | Y | M | T | N | Y | W | V | L | I | R | . | G | Q | W | . | L | E | W | . |
| nurse shark Gici UBA | V | . | H | F | I | V | L | F | K | L | A | M | H | F | Y | I | F | . | Y | M | V | N | F | W | L | I | I | R | . | N | E | W | F | L | E | W | . |
| african clawed frog Xela UAA | L | . | Y | F | T | E | D | . | E | K | S | I | T | F | N | V | A | . | V | W | Y | E | H | Y | . | F | . | . | . | A | R | N | . | L | I | G | . |
| chiken Gaga BF2 | L | . | R | F | D | M | A | . | E | I | V | S | I | N | N | I | L | . | V | W | S | H | A | Y | . | V | . | . | . | Y | G | L | . | L | T | W | . |
| chicken Gaga BF1 | L | . | H | Y | D | V | Y | . | Q | I | G | N | S | V | S | T | L | . | V | W | F | R | V | Y | . | I | . | . | . | V | G | W | . | L | T | W | . |
| mouse Mumu H2D | . | . | E | Y | S | V | Y | . | E | K | A | Q | W | F | S | N | L | Y | L | Q | S | L | F | Y | Y | I | . | . | . | A | H | Y | . | L | E | W | . |
| human Hosa HLA-E | L | . | H | F | S | V | M | . | E | S | A | T | I | F | N | T | L | Y | L | W | H | E | F | Y | Y | L | S | . | S | E | H | Q | . | L | T | W | . |
| human Hosa HLA-A2 | M | . | F | F | A | V | M | . | E | K | V | H | T | H | D | T | L | Y | L | M | F | H | Y | Y | Y | I | . | . | . | V | Q | L | . | L | T | W | . |
| coelacanth Lach U | - | - | - | - | - | N | Y | S | E | T | R | P | Y | G | F | I | A | . | V | R | Y | F | D | Y | . | I | . | . | . | M | Q | W | . | L | I | W | . |
| lung fish Pran U | L | . | Y | F | A | I | A | . | N | N | L | A | A | F | N | I | A | . | A | T | Y | R | E | Y | Y | L | . | . | . | F | Q | R | . | L | T | W | . |
| chinese sturgeon Acsi U | L | . | Y | F | A | D | D | . | N | K | C | H | N | F | N | I | A | . | A | T | L | W | E | Y | Y | I | . | . | . | R | Y | L | . | L | T | W | . |
| spotted garm Leoc U | Y | . | Y | F | V | N | M | F | G | I | L | W | T | F | G | I | L | . | W | L | Y | F | F | Y | Y | I | . | . | . | D | F | Q | . | L | T | W | . |
| stickleback Gaac U | L | . | Y | F | I | V | L | F | Q | L | A | A | E | F | Y | T | A | . | V | N | Y | D | Y | Y | . | I | I | . | . | L | G | K | F | L | E | G | F |
| fugu Taru U | L | . | Y | F | I | V | M | . | Q | N | A | A | I | Y | N | I | A | . | Y | N | Y | F | D | Y | . | I | . | . | . | G | Q | L | . | Y | I | W | . |
| tilapia Orni U | L | . | L | F | V | D | A | . | E | N | C | S | S | F | N | T | A | . | V | R | Y | R | D | Y | . | I | . | . | . | T | Q | Y | . | L | I | W | . |
| medaka Orla U | L | . | Y | F | S | S | T | . | N | N | F | S | V | Y | N | V | A | . | Y | N | Y | R | F | Y | . | I | . | . | . | G | Y | W | . | L | I | W | . |
| elephant shark Cami UDA | L | . | Y | F | H | T | N | E | E | K | L | R | L | Y | N | I | A | . | I | Y | S | R | Y | F | L | L | . | . | . | E | Y | K | . | S | I | W | . |
| little skate Leer UDA | L | . | Y | F | H | T | D | . | E | R | L | R | L | Y | N | I | A | . | L | Y | S | R | Y | F | L | I | . | . | . | N | Y | K | . | T | I | W | . |
| whale shark Rhty UDA | L | . | Y | F | H | T | D | . | E | R | L | R | L | C | N | I | A | . | L | Y | S | R | Y | F | L | I | . | . | . | D | Y | K | . | T | I | W | . |
| nurse shark Gici UDA | L | . | Y | F | H | T | D | . | E | R | L | R | L | S | N | I | A | . | L | Y | S | R | Y | F | L | I | . | . | . | D | Y | K | . | T | I | W | . |
| blue shark Prgl UDA | L | . | Y | F | H | T | D | . | E | R | L | R | L | S | N | I | A | . | L | Y | S | R | Y | F | . | I | . | T | . | D | Y | K | . | T | I | W | . |
| spotted catshark Scca UDA | L | . | Y | F | H | T | D | . | E | R | L | R | L | S | N | I | A | . | L | Y | S | R | Y | F | L | I | . | . | . | D | Y | K | . | T | I | W | . |
| spoted gar Leoc Z | L | . | Y | I | E | R | K | . | G | S | R | K | W | F | N | I | L | . | L | W | H | D | Y | Y | . | L | . | . | . | L | Y | T | . | L | E | W | F |
| tetraodon Teni Z | L | . | Y | I | E | H | K | . | G | S | R | K | W | F | N | I | L | . | L | W | H | D | Y | Y | . | L | . | . | . | L | Y | T | . | L | E | W | F |
| zebra fish Dare Z | L | . | Y | I | E | R | K | . | G | S | R | K | W | F | N | I | L | . | L | W | H | D | Y | Y | . | L | . | . | . | L | Y | T | . | L | E | W | F |
| spiny dogfish Scca UCA | L | V | H | F | A | M | V | Q | E | S | A | A | I | M | G | N | T | L | F | W | K | V | F | F | . | I | L | Q | F | W | T | W | N | L | T | G | L |
| human Hosa CD1 | F | V | Q | T | G | H | A | E | L | I | F | Y | G | F | E | D | F | D | I | G | A | L | G | L | . | L | F | L | I | I | T | V | L | L | T | Y | V |
| chicken Gaga CD1 | L | L | H | V | G | G | I | D | I | S | I | Y | D | F | L | M | Y | V | F | S | I | F | I | Y | . | L | E | M | A | L | V | I | L | L | T | I | F |
The 9 invariant residues that bind to the N- (light gray) and C-termini (dark gray) of bound peptides found in the classical class I and 28 other predicted peptide binding residues are shown. The dots in the 9 invariant residues indicate the same amino acids present in the reference sequence, nurse shark Gici UAA. The UDA peptide-banding hydrophilic or charged residues are indicated in bold.
*
The position of peptide binding residues is based on the Human HLA-A2 sequence. Sequence information listed in Supplemental Table 1.