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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Endocr Relat Cancer. 2019 Nov;26(11):803–814. doi: 10.1530/ERC-19-0325

Table 3.

New types of ALK rearrangements detected in thyroid cancer

Fusion name Cytogenetic characteristics Dimerization domain of
ALK fusion partner		 Encoding ALK
exones		 Predicted protein
size
ITSN2 e29-ALK e18 t(2;2);(p23.3;p23.2) Coiled-coil e18-e29 1841 aa
PPP1R21 e9/i9-ALK e20 t(2;2);(p16.3;p23.2) Coiled-coil e20-e29 844 aa
PPP1R21 e7-ALK e20 t(2;2);(p16.3;p23.2) Coiled-coil e20-e29 794 aa
CTSB e1-ALK e16 t(8;2);(p23.1;p23.2) None* e16-e29 711 aa*
CTSB e1-ALK e17 t(8;2);(p23.1;p23.2) None* e17-e29 671 aa*
*

Translation start codon in ALK exon16 or ALK exon 17; exon 1 of the partner gene untranslated