Figure 1. Click-functionalized LbL NPs remain stable and exhibit protease-responsive behavior.
(a) Diameter, polydispersity index, and (b) zeta potential of click-modified LbL NPs. (c) In vitro cleavage of biosensor LbL NPs in the presence of MMP9. Nanoparticle modifications are abbreviated as follows: biosensor peptide (+S), iRGD targeting peptide (+R), and PEG pendants (+P). Error bars represent standard deviation, and statistical analysis of panel b uses one-way ANOVA with a Dunnett post-hoc test and alpha of 0.05.