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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Cancer Res. 2019 Nov 5;80(3):524–535. doi: 10.1158/0008-5472.CAN-18-3985

Figure 2: The oxidative phosphorylation gene program is elevated in resistant cells.

Figure 2:

(A) GSEA hallmark pathways positively enriched with nominal p-value<0.05 and FDR q-value<0.1 in resistant pools versus BT474 parental cells (left). NES scores of each resistant pool for pathways enriched in all pools compared to BT474 cells (right). (B-C) GSEA enrichment plots of the hallmark oxidative phosphorylation pathway for BT-TR2 (B) and BT-TPR1 (C) versus BT474 parental cells. (D) GSEA hallmark pathways negatively enriched with nominal p-value<0.05 and FDR q-value<0.1 in resistant pools versus BT474 parental cells (left). NES scores of each resistant pool for pathways enriched in all pools compared to BT474 cells (right, top) or in BT-TPR pools only (right, bottom). (E) GSEA enrichment plots of the hallmark estrogen response early pathway for BT-TR2 versus BT474 parental cells. (F) GSEA enrichment plots of the hallmark epithelial mesenchymal transition pathway for BT-TPR1 versus BT474 parental cells. (G) GSEA enrichment plots of the hallmark IL6 JAK STAT3 signaling pathway for BT-TPR1 versus BT474 parental cells.