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. Author manuscript; available in PMC: 2021 Jan 1.
Published in final edited form as: Cytoskeleton (Hoboken). 2019 Dec 27;77(1-2):25–35. doi: 10.1002/cm.21591

Fig. 7. Models for CCDC103 Molecular Scaffolds.

Fig. 7

Two possible mechanisms by which CCDC103 might oligomerize to form scaffolds. The “molecular ladder” model envisages oligomerization through the RPAP3_C domain/C-terminal regions combined with dimerization of two scaffolds through the inherently disordered regions. In contrast, the “beads on a string” model would be compatible with the presence of two dimerization interfaces and the ability of CrCCDC103 to form stable tetramers. However, in both cases CCDC103 oligomers would retain unassociated N- and C-terminal coiled coil domains which remain available for interactions with other axonemal components.