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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Mol Cancer Res. 2019 Nov 8;18(2):264–277. doi: 10.1158/1541-7786.MCR-19-0748

Figure 6: LSD1 is required for EGF-induced migration of cells with an active AKT-GSK3β-Snail axis.

Figure 6:

(A) 10x bright field images of crystal violet stained HT29 cells after 48H migration through transwell insert. WT, LSD1 KO, 10 μM GSK690693 or 3 μM corin cells were co-treated with 100 ng/mL EGF for 48H. (B) Quantification of migration normalized to migration counts for untreated cells. Results are represented as mean ± SD. Significance was determined by one-way ANOVA with Tukey’s multiple comparisons test. All significant comparisons are shown. adj. p-value; ****<.0001. (C) shEV or shLSD1 cells were treated with 100 ng/mL EGF for 24H or 48H and analyzed by western blot. (D) Model depicting CoREST complex in the regulation of AKT.