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Cytotoxicity, anti-coxsackievirus B3, anti-rhinovirus activity and selectivity indexes of the most promising compound 10g
| No | CC50, μM | IC50 towards coxsackievirus B3 (mean, μM) and SI |
IC50 towards rhinovirus (mean, μM) and SI |
||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 97927 | Nancy | A2 | B5 | B14 | |||||||||||||
| I1207/I1092 | I1207K/I1092 | I1207M/I1092 | I1207T/I1092 | ||||||||||||||
| mean | SI | mean | SI | mean | SI | mean | SI | mean | SI | mean | SI | mean | SI | mean | SI | ||
| 10g | 13.38 | 0.02 | 669 | 4.79 | 2.8 | 0.01 | 1338 | 0.01 | 1338 | 2.76 | 4.9 | 0.86 | 15.6 | 5.25 | 2.6 | 0.09 | 149 |
