Figure 4. Assessment of muscle strength and neuromuscular function.

Physical function measurements in 20-month-old male mice treated with dasatinib and Quercetin (D+Q) once every 2 weeks (bi-weekly) for 4 months. (a) Grip strength, (b) hanging endurance, and (c) maximal walking speed on rotarod (relative to baseline) 4 months after drug initiation (n = 13 vehicle-treated and 20 D+Q-treated biologically independent animals per group, *P <0.05; n.s., not significant; Two-tailed Student’s t-tests). Results are shown as box and whiskers plots, where a box extends from the 25th to 75th percentile with the median shown as a line in the middle, and whiskers indicate smallest and largest values. Figure is adapted from Xu et al., 2018, Nature Medicine³⁴ with permission. Animal procedures were performed following approval by the Mayo Clinic Institutional Animal Care and Use Committee.