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. 2020 Feb 5;5(1):e00826-19. doi: 10.1128/mSphere.00826-19

FIG 5.

FIG 5

gC contributes to rapid HSV penetration following endocytosis. HSV-1 ΔgC or gCR was bound to CHO-HVEM (A) or HEKa (B) cells for 1 h at 4°C (MOI of 8). Following a shift to 370C, extracellular virions were subjected to citrate inactivation at the indicated times p.i. Titers of freeze-thaw cell lysates were determined on Vero cells as an indication of infectious, enveloped, intracellular particles. This allows monitoring of viral trafficking and penetration over time. Peak recovery titers were set to 100%. Data are representative of results from at least two independent experiments.