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. 2020 Jan 30;10:930. doi: 10.3389/fendo.2019.00930

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Copyright © 2020 Fu, Gao, Zhang, Dai, Zou and Yue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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βE2 blocked the internalization of PCSK9. (A) Alexa Fluor 488 dye-labeled PCSK9 (25 μg/mL) was added to HepG2 cells not treated with βE2. ^AF−PCSK9 internalization was observed at specified time intervals. (B) Internalization of ^AF−PCSK9 was blocked at the cell surface by βE2 administered at specified concentration ranges. (C,D) Quantification of ^AF−PCSK9. The relative fluorescent unit (RFU) of ^AF−PCSK9 was determined by ZEISS 2010 software. Values represent the means ± SEM, n = 3; *P < 0.05 for a comparison between two groups.