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. 2020 Jan 30;10:930. doi: 10.3389/fendo.2019.00930

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Copyright © 2020 Fu, Gao, Zhang, Dai, Zou and Yue.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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βE2 treatment prevented the PCSK9-induced recruitment of clathrin. (A) HepG2 cells were incubated in the presence of rhPCSK9 (25 μg/mL), and clathrin levels were measured the specified time intervals. (B) HepG2 cells were treated with βE2 (0.01–1 μM) for 2 h in the presence of rhPCSK9 and were visualized for the detection of immunofluorescence-stained clathrin. The fluorescent quantification of clathrin was determined by ZEISS 2010 software. Values represent the means ± SEM, n = 3; *P < 0.05 for a comparison between two groups.