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. 2020 Feb 4;11(1):e03256-19. doi: 10.1128/mBio.03256-19

FIG 5.

FIG 5

Effect of H. pylori-mediated binding to CEACAM-humanized PMNs, DCs, or macrophages on the secretion of the chemokines MIP-1α (CCL3), KC (CXCL1), and MCP-1 (CCL2). (A to C) Analysis of the production and secretion of MIP-1α (A), KC (B), or MCP-1 (C) from PMNs, DCs, or macrophages of wt or CEACAM-humanized mice left uninfected or infected for 3 h (MOI of 60) with H. pylori P12. Incubation of cells with 200 ng/ml LPS for 3 h was used as a positive control. Cells were analyzed with the LEGENDplex mouse proinflammatory chemokine 13-plex panel (BioLegend). Data were assessed using two-way ANOVA and the Bonferroni post hoc test. *, P < 0.05; **, P < 0.01; ***, P < 0.001.