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. 2020 Feb 5;10:1897. doi: 10.1038/s41598-020-58443-3

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Protective effect of the IGEs against lethal IAV challenge to Balb/c mice. The mice were infected with intranasally with an influenza virus strain A/FM/1/47 solution and then treated with IGEs for 5 days. The body weight changes were determined by measurements taken 0, 4 8, 11, and 14 days post-infection, and the number of deaths in each group was recorded for 14 consecutive days (n = 20). (A) Body weight change curves for the 14 consecutive days. (B) Survival rate of the IAV- infected mice treated with IGEs (20, 10, 5 mg/kg) for 14 consecutive days. (C) IGEs treatment increased the survival time (days) of mice in a dose-dependent manner, ^##p < 0.01 compared to the virus control group.