Table 1.

Summary of histopathologic measurements obtained from each of the evaluated tissue sections during all three animal studies.

Histopathologic evaluation
Tissue location	Obtained measurements
Proximal jejunum Mid jejunum Distal jejunum Ileum	Neutrophil count* Ulceration score†
Cecum Apex of spiral colon Mid spiral colon Rectum	Neutrophil count* Crypt depth‡ Ulceration score†
Ileocecal lymph node Spleen Liver	Neutrophil presence§

FOV, field of view; TNTC, too numerous to count.

^*Average of 5 neutrophil counts; at 400X FOV, >100 neutrophils in one FOV was considered TNTC and listed as 100.

^†Number of crypts over which most severe ulceration foci extended, ranging from 0 to 5 (5 = ulcer spanning five or more crypts).

^‡Average of three crypt depths measured at 10X FOV.

^§Presence or absence of neutrophils (in any amount) in 5-400X FOV, ranging from 1 to 5 (1 = no neutrophils observed in 5 FOV, 5 = neutrophils observed in all 5 FOV).