Fig. 1. Patient-derived AML xenografts undergo extensive clonal competition across multiple generations.

Latency (a) and engraftment levels (b) in primary recipient mice, identically ordered by average disease latency. Risk categories were based on the ELN 2017 guidelines. c Engraftment of primary AML samples based on the presence of recurrent AML mutations. d Schematic overview of the generation and nomenclature of PDXs. e Patterns of clonal dynamics identified as leukemias were transplanted to primary and secondary recipient mice. n denotes the number of cases that follow each pattern.