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. 2020 Feb 5;10:1850. doi: 10.1038/s41598-020-58732-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of Platelet-rich fibrin (PRF) application on gingival inflammation. The inflammatory score was calculated from tissue samples at day 14 after surgery and treatment. The control was the sham operation in dogs with healthy periodontium. OFD represents the groups that exhibited periodontal disease and were treated with open flap debridement alone. OFD + PRF refers to the groups that exhibited periodontal diseases and were treated with open flap debridement and PRF application. Bars indicate a significant difference between groups.