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. 2020 Feb 5;10:1854. doi: 10.1038/s41598-020-58906-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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The animal experimental schedule. After tumor induction by tail vein injection of cells of the Lewis lung carcinoma line, the mice of the CIH group were exposed to intermittent hypoxia-inducing conditions for 2 weeks, while those of the control group breathed room air. At 3 weeks, the mice were sacrified and cancer growth was measured. LLC: Lewis lung carcinoma.