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. 2020 Feb 5;10:1854. doi: 10.1038/s41598-020-58906-7

Figure 2.

Figure 2

Effects of CIH on the histopathologic changes and tumor growth in lung tissue in a mouse model of LLC. (A) Representative images of gross lung examination in LLC mice. (B) Photographs of the dissected tumors and representative images of hematoxylin and eosin stained lung sections. The two top panels show images of whole lung sections and higher magnification of the same samples (magnification, x400). Lung tumor development was evaluated according to (C) the number of tumors and (D) the tumor volume in each group at the study endpoint. The data represent the mean ± SD. *p < 0.05, **p < 0.01 compared with RA controls. CIH: chronic intermittent hypoxia; LLC: Lewis lung carcinoma; RA: room air; SD: standard deviation.