Participant timeline
	Within 28 days (4 weeks) prior to randomization	Within 7 days prior to randomization	Within 1 day prior to randomization
Medical history	X
Adverse event assessment (CTCAE v5.0)		X
Physical examination 1		X
Performance status		X
HBV, HCV, HIV serology		X
Endocrine function2	X
12-lead ECG (in triplicate) (2–5 min apart)	X
LVEF (by MUGA or ECHO), only if indicated	X
Disease assessment3	X
Surgery assessment¥	X
Review of prior/concomitant medications		X
Quality of Life questionnaire (QLQ-C30)		X
G8 screening for frailty for patients older than 70		X
Hematology4		X(A)
Serum chemistry5		X(A)
Urine analysis		X(A)
Pregnancy test6			X(B)
FFPE sample of biopsy	X
FFPE sample of resection	X