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. 2020 Feb 5;10:1886. doi: 10.1038/s41598-020-58701-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Cellular metabolomes at different expression of the OGDHC and OADHC components. (A) Relative mRNA levels for the enzymatic components of OGDHC and OADHC in C6 and MCF-7 cell lines. The shown transcript abundances are averaged from ≥8 independent experiments for each cell line. D/O is the ratio between the expression of DHTKD1 and OGDH + OGDHL mRNAs. (B) Ratios of mRNA levels for the second and the first components of OADHC and OGDHC. (C) Relative metabolite abundances in the MCF-7 cell line compared to the C6 cell line. The asterisks show significant differences between the cell lines according to t-test. Experimental groups and metabolites are clustered using Manhattan as a distance measure and WPGMA as an agglomeration method. Number of independent experiments for each experimental group (n) is indicated at the bottom of the heatmap. (D) Cell-specific metabolites, i.e. those which are reliably quantified only in one of the two cell lines, are marked by “+” in the cell line where they are detected, and by “−” in the another one.