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. 2020 Jan 30;13:7. doi: 10.3389/fnmol.2020.00007

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Copyright © 2020 Xu, Zheng, Yin, Xu, Tian, Zhang, Wang and Ma.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Bodyweight (g) responses in the experimental groups during the experimental weeks (A). The percentage of body weight change between week 0 and week 8 in the experimental groups (B). The effects of NT and OT group on the exhaustion velocity (EV), as determined during the ILT during weeks 0 and 8 (C). The data represent the means ± SE of n = 15. CON: sedentary mice; NT: mice trained with adequate recovery; OT: mice that underwent the downhill running OT protocol. *Statistical significance (P < 0.05); ***statistical significance (P < 0.001); ****statistical significance (P < 0.0001).