Table 1.
Loci associated with a genome-wide significant threshold after the cross-disease meta-analysis of systemic sclerosis and Crohn’s disease.
| Discovery | Replication | Discovery + Replication | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SSc | CD | SSc-CD | SSc | CD | SSc-CD | ||||||||
| Region | Gene | SNP | Test Allele | P-value | OR | P-value | OR | P-value | P-value | OR | P-value | OR | P-value |
| 1p31.3 | IL12RB2 | rs6659932 | A | 2.47E-08 | 1.3 | 1.33E-04 | 0.79 | 1.54E-11 | 3.75E-03 | 1.13 | 3.44E-02 | 0.86 | 1.08E-11 |
| 5q31.1 | IRF1 | rs2548998 | G | 1.55E-03 | 1.27 | 3.09E-07 | 0.79 | 1.13E-08 | 2.00E-02 | 1.08 | 1.18E-03 | 0.88 | 2.18E-11 |
| 6p21.31 | ZBTB9/BAK1 | rs68191 | C | 8.15E-03 | 0.84 | 8.70E-06 | 1.39 | 8.33E-07 | 2.09E-04 | 0.82 | 1.56E-02 | 1.15 | 1.07E-10 |
| 17q21.2 | STAT3 | rs4796791 | T | 1.34E-03 | 1.13 | 1.52E-04 | 0.84 | 9.86E-07 | 3.85E-02 | 1.08 | 1.85E-02 | 0.90 | 2.52E-08 |
Results of the discovery and replication analysis for each individual disease and of the combined meta-analysis (discovery + replication) are shown.
SNP, single-nucleotide polymorphism; SSc, systemic sclerosis; CD, Crohn’s disease.