Table 3.
Risk factors for any hepatic metastasis postoperatively
| Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| Hazard ratio | 95% CI | P value | Hazard ratio | 95% CI | P value | |
| Liver fibrosis score | ||||||
| NFS | 1.677 | 1.213–2.319 | 0.002 | 1.664 | 1.189–2.329 | 0.003 |
| FIB4 | 1.439 | 1.109–1.867 | 0.006 | 1.453 | 1.106–1.909 | 0.007 |
| APRI | 1.816 | 1.028–3.209 | 0.04 | 2.34 | 1.311–4.176 | 0.004 |
| Male gender | 1.555 | 1.098–2.203 | 0.013 | 1.49 | 1.049–2.116 | 0.026 |
| Age > 70 | 1.508 | 1.043–2.181 | 0.029 | 1.521 | 1.031–2.244 | 0.034 |
| T stage | ||||||
| T1 | Reference | Reference | ||||
| T2 | 1.536 | 0.735–3.210 | 0.254 | 1.456 | 0.696–3.046 | 0.319 |
| T3 | 2.416 | 1.086–5.379 | 0.031 | 1.789 | 0.788–4.064 | 0.165 |
| T4 | 2.945 | 1.483–5.848 | 0.002 | 2.168 | 1.080–4.352 | 0.03 |
| N stage | ||||||
| N0 | Reference | |||||
| N1 | 1.456 | 1.012–2.094 | 0.043 | 0.174 | 0.893–1.862 | 0.174 |
| N2 | 1.022 | 0.592–1.765 | 0.938 | 0.981 | 0.581–1.744 | 0.981 |
| Location | ||||||
| Right-sided colon | Reference | Reference | ||||
| Left-sided colon | 0.616 | 0.383–0.991 | 0.046 | 0.702 | 0.434–1.138 | 0.151 |
| Rectum | 0.546 | 0.378–0.788 | 0.001 | 0.749 | 0.496–1.130 | 0.168 |
| Lymph node examined | 1.017 | 0.993–1.041 | 0.157 | |||
| Mucinous Adenocarcinoma | 1.756 | 1.073–2.876 | 0.025 | 1.39 | 0.839–2.304 | 0.202 |
| Perineural invasion | 1.298 | 0.845–1.996 | 0.234 | |||
| Vascular invasion | 1.333 | 0.909–1.954 | 0.142 | |||
| Adjuvant therapy | 2.983 | 1.987–4.476 | < 0.001 | 2.726 | 1.782–4.171 | < 0.001 |
| Diabetes mellitus | 0.996 | 0.584–1.700 | 0.99 | |||
| Obesity (BMI > 25) | 1.292 | 0.913–1.831 | 0.149 | |||