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. 2016 Oct 27;122(1):68–75. doi: 10.1152/japplphysiol.00714.2016

Fig. 1.

Fig. 1.

Genes related to TLR signaling, inflammation, and ceramide metabolism in HipFx in response to exercise training. Individual data values for genes related to toll-like receptor signaling (A), inflammatory mediators (B), and ceramide metabolism (C) in HipFx (n = 7) skeletal muscle after 3 mo of exercise training (relative to Pre). Data were normalized to beta2-microglobulin (B2M) using the 2–ΔΔCt method; therefore values for Pre were ~1 (dotted line). Open bar represents the mean. *Different from Pre (P ≤ 0.05). TLR2, toll-like receptor 2; TLR4, toll-like receptor 4; RAGE, receptor for age-related glycation; MYD88, myeloid differentiation primary response gene 88; TRAF6, TNF receptor-associated factor 6; TAK1, transforming growth factor beta-activated kinase 1; NFKB1, nuclear factor kappa beta 1; IL6, interleukin 6; MCP1, monocyte chemoattractant protein-1; HMGB1, high-mobility group box protein 1; SPT1, serine palmitoyltransferase 1 (SPT1); SPT2, serine palmitoyltransferase 2; CERS1, ceramide synthase 1; CERS2, ceramide synthase 2; SPHK1, sphingosine kinase 1.