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Treatment with GBT1118 improved outcomes of mice exposed to LPS + 5% hypoxia. GBT1118 significantly improved survival with LPS + hypoxia compared with vehicle-treated mice (A), P = 0.032 by log rank. Treatment with 140 mg/kg GBT1118 improved severity of illness scores (B) compared with vehicle at 5% hypoxia but had no significant effects on severity of illness in 10% hypoxia, *P = 0.014, n = 15–18 in each group.
