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Administration of GBT1118 decreases tissue hypoxia. Mice were treated with LPS and exposed to 10% hypoxia. Administration of high-dose GBT1118 significantly decreased the intensity of Hypoxyprobe staining compared with vehicle-treated mice in both the kidney (A–C) and liver (D–F), n = 9–10 in each group. *P = 0.043.
