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Seminal experiments (Refs. 64 and 65) with anesthetized cats showed that electrical stimulation of the ventral root of the spinal cord, or capsaicin injection into the hindlimbs (A), produced an increase in activity of group IV fibers, which was accompanied by increases in heart rate (HR) and mean arterial pressure (B). The black arrow in B illustrates the beginning of stimulation (either by capsaicin or an electrical stimulus).
