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. 2019 Nov 6;28(24):4089–4102. doi: 10.1093/hmg/ddz254

Figure 6.

Figure 6

SAHA impacts on alr-1 mutant function and neuron differentiation through rbr-2.(A, B) SAHA was able to rescue gentle touch sensitivity in alr-1(KO) adult animals but not in alr-1(KO);rbr-2(KO) double mutants. Each dot corresponds to an individual animal stimulated 10 times (N = 30 for mutants and WT animals tested). The mean and the 95% confident interval are shown. Asterisks indicate statistical significance (one-way ANOVA test with Bonferroni correction; *P < 0.05, ***P < 0.0005, ****P < 0.0001) compared with untreated (Nt) or DMSO-treated animals (V). n.s. indicates a not significant difference. (C) Diagram of the 19 GABAergic motor neuron cell bodies ventrally located in WT animals, subdivided in six DDs (in orange) and 13 VDs (in yellow). (D) Partial rescue of defective development of GABAergic motor neurons in alr-1(KO) mutants after SAHA treatment. Confocal images of an adult WT animal and alr-1(KO) mutants expressing a transgene that allows the visualization of the DD motor neurons, indicated by arrowheads. Scale bar is 100 μm. The anterior of the animal is to the left, ventral is down in (C) and (D).