Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Jan 30;10:3154. doi: 10.3389/fmicb.2019.03154

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Hatherill, White and Hawn.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Target populations for new TB vaccines include Mtb-uninfected (pre-exposure) and Mtb-infected, TB diseased, and treated individuals (post-exposure). Risk of Mtb infection and progression to TB disease increases with age (time at risk). Pre-exposure strategies for TB vaccination of Mtb-uninfected individuals include both prevention of infection (POI) and prevention of disease (POD). Post-exposure strategies include vaccination of Mtb-infected individuals to prevent progression to TB disease (POD); vaccination of TB patients to improve treatment outcomes (therapeutic); and vaccination of treated TB patients to prevent recurrent disease (POR). Therapeutic vaccination might also confer POR benefit.